Sonodynamically-induced antitumor effect of mono-1-aspartyl Chlorin e6 (NPe6)

Nagahiko Yumita, Yumiko Iwase, Koji Nishi, Toshihiko Ikeda, Hajime Komatsu, Toshio Fukai, Kenji Onodera, Hiroyoshi Nishi, Kazuyoshi Takeda, Shin Ichiro Umemura, Kazuho Okudaira, Yasunori Momose

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Background: The sonodynamically-induced in vitro and in vivo antitumor effects of mono-l-aspartyl chlorin e6 (NPe6) was investigated. Materials and Methods: Both in vitro and in vivo antitumor effects were tested in combination with ultrasound at 2 MHz. Results: The rate of ultrasonically-induced damage on isolated sarcoma 180 cells in air-saturated suspension was enhanced two-fold with 80 μM NPe6. The co-administration of 25 mg/kg NPe6 followed by ultrasonic exposure at 2 MHz suppressed the growth of implanted colon 26 cell tumors at an intensity at which ultrasound alone showed only a slight antitumor effect. Conclusion: These in vitro and in vivo results suggest that NPe6 is a potential sensitizer for sonodynamic tumor treatment. The enhancement of cell damage by NPe6 was significantly inhibited by histidine, which may suggest reactive oxygen species plays a primary role in sonodynamically-induced antitumor effect.

Original languageEnglish
Pages (from-to)501-506
Number of pages6
JournalAnticancer research
Volume31
Issue number2
Publication statusPublished - 2011 Feb

Keywords

  • Antitumor effect
  • Colon 26
  • Mono-l-aspartyl chlorin e6
  • Sarcoma 180
  • Sonodynamic therapy
  • Ultrasound

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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