Sonodynamically induced antitumor effect of a gallium-porphyrin complex, ATX-70

Nagahiko Yumita, Kazuaki Sasaki, Shin Ichiro Umemura, Ryuichiro Nishigaki

Research output: Contribution to journalArticlepeer-review

75 Citations (Scopus)

Abstract

The sonodynamically induced antitumor effect of a gallium-porphyrin complex, ATX-70, was evaluated in mice bearing colon 26. In order to find the optimum timing for the ultrasonic exposure after the administration of ATX-70, the ATX-70 concentrations in the plasma, skin, and tumor were measured and analyzed. Antitumor effect was estimated by measuring the tumor size. When used alone, ultrasound showed a slight antitumor effect, which became increasingly significant as the dose of ATX-70 was increased, while use of ATX-70 alone had no significant effect. At an ATX-70 dose of 2.5 mg/kg or higher, the average tumor size decreased to smaller than a half by three days after the ultrasonic exposure. This was smaller than a third of the size of the untreated tumors on the same day. From these results, it is concluded that ATX-70 significantly sensitizes tumors to ultrasound, demonstrating a synergistic antitumor effect.

Original languageEnglish
Pages (from-to)310-316
Number of pages7
JournalJapanese Journal of Cancer Research
Volume87
Issue number3
DOIs
Publication statusPublished - 1996 Mar

Keywords

  • Antitumor effect
  • Colon 26
  • Porphyrin complex
  • Sonodynamic therapy
  • Ultrasound

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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