TY - JOUR
T1 - Sonodynamically induced antitumor effect of a gallium-porphyrin complex, ATX-70
AU - Yumita, Nagahiko
AU - Sasaki, Kazuaki
AU - Umemura, Shin Ichiro
AU - Nishigaki, Ryuichiro
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1996/3
Y1 - 1996/3
N2 - The sonodynamically induced antitumor effect of a gallium-porphyrin complex, ATX-70, was evaluated in mice bearing colon 26. In order to find the optimum timing for the ultrasonic exposure after the administration of ATX-70, the ATX-70 concentrations in the plasma, skin, and tumor were measured and analyzed. Antitumor effect was estimated by measuring the tumor size. When used alone, ultrasound showed a slight antitumor effect, which became increasingly significant as the dose of ATX-70 was increased, while use of ATX-70 alone had no significant effect. At an ATX-70 dose of 2.5 mg/kg or higher, the average tumor size decreased to smaller than a half by three days after the ultrasonic exposure. This was smaller than a third of the size of the untreated tumors on the same day. From these results, it is concluded that ATX-70 significantly sensitizes tumors to ultrasound, demonstrating a synergistic antitumor effect.
AB - The sonodynamically induced antitumor effect of a gallium-porphyrin complex, ATX-70, was evaluated in mice bearing colon 26. In order to find the optimum timing for the ultrasonic exposure after the administration of ATX-70, the ATX-70 concentrations in the plasma, skin, and tumor were measured and analyzed. Antitumor effect was estimated by measuring the tumor size. When used alone, ultrasound showed a slight antitumor effect, which became increasingly significant as the dose of ATX-70 was increased, while use of ATX-70 alone had no significant effect. At an ATX-70 dose of 2.5 mg/kg or higher, the average tumor size decreased to smaller than a half by three days after the ultrasonic exposure. This was smaller than a third of the size of the untreated tumors on the same day. From these results, it is concluded that ATX-70 significantly sensitizes tumors to ultrasound, demonstrating a synergistic antitumor effect.
KW - Antitumor effect
KW - Colon 26
KW - Porphyrin complex
KW - Sonodynamic therapy
KW - Ultrasound
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U2 - 10.1111/j.1349-7006.1996.tb00222.x
DO - 10.1111/j.1349-7006.1996.tb00222.x
M3 - Article
C2 - 8613435
AN - SCOPUS:0029870379
VL - 87
SP - 310
EP - 316
JO - Cancer Science
JF - Cancer Science
SN - 1347-9032
IS - 3
ER -