Sonodynamically induced antitumor effect of 4-Formyloximethylidene-3-hydroxy-2-vinyl-deuterio-porphynyl(IX)-6, 7-diaspartic acid (ATX-S10)

Nagahiko Yumita, Ryuichiro Nishigaki, Isao Sakata, Susumu Nakajima, Shin Ichiro Umemura

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55 Citations (Scopus)

Abstract

The sonodynamically induced antitumor effect of 4-formyloximethylidene-3-hydroxy-2-vinyl-deu-terio-porphynyl(IX)-6,7-diaspartic acid (ATX-S10) was investigated. Both in vitro and in vivo antitumor effects were tested in combination with ultrasound at 2 MHz. The rate of ultrasonically induced damage to isolated sarcoma 180 cells in air-saturated suspension was enhanced two-fold with 80 μM ATX-S10. This enhancement was significantly inhibited by histidine, which may suggest that it was mediated by ultrasonically induced oxidation. The coadministraion of 25 mg/kg ATX-S10 followed by ultrasonic exposure at 2 MHz stopped the growth of implanted colon 26 tumors at an intensity at which ultrasound alone showed only a slight antitumor effect.

Original languageEnglish
Pages (from-to)255-260
Number of pages6
JournalJapanese Journal of Cancer Research
Volume91
Issue number2
DOIs
Publication statusPublished - 2000 Feb

Keywords

  • ATX-S10
  • Antitumor effect
  • Colon 26
  • Sarcoma 180
  • Sonodynamic therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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