Sonodynamic therapy with anticancer micelles and high-intensity focused ultrasound in treatment of canine cancer

Yuki Horise, Masanori Maeda, Yoshiyuki Konishi, Jun Okamoto, Soko Ikuta, Yoshiharu Okamoto, Hiroshi Ishii, Shin Yoshizawa, Shinichiro Umemura, Tsuyoshi Ueyama, Satoshi Tamano, Atsushi Sofuni, Kazuhisa Takemae, Ken Masamune, Hiroshi Iseki, Nobuhiro Nishiyama, Kazunori Kataoka, Yoshihiro Muragaki

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Sonodynamic therapy (SDT) is a minimally invasive anticancer therapy involving a chemical sonosensitizer and high-intensity focused ultrasound (HIFU). SDT enables the reduction of drug dose and HIFU irradiation power compared to those of conventional monotherapies. In our previous study, mouse models of colon and pancreatic cancer were used to confirm the effectiveness of SDT vs. drug-only or HIFU-only therapy. To validate its usefulness, we performed a clinical trial of SDT using an anticancer micelle (NC-6300) and our HIFU system in four pet dogs with spontaneous tumors, including chondrosarcoma, osteosarcoma, hepatocellular cancer, and prostate cancer. The fact that no adverse events were observed, suggests the usefulness of SDT.

Original languageEnglish
Article number545
JournalFrontiers in Pharmacology
Volume10
Issue numberMAY
DOIs
Publication statusPublished - 2019

Keywords

  • Anticancer micelles
  • Drug delivery system
  • High-intensity focused ultrasound
  • Minimally invasive
  • Sonodynamic therapy

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Sonodynamic therapy with anticancer micelles and high-intensity focused ultrasound in treatment of canine cancer'. Together they form a unique fingerprint.

Cite this