TY - JOUR
T1 - Sonodynamic therapy on chemically induced mammary tumor
T2 - Pharmacokinetics, tissue distribution and sonodynamically induced antitumor effect of porfimer sodium
AU - Yumita, Nagahiko
AU - Okuyama, Nobuo
AU - Sasaki, Kazuaki
AU - Umemura, Shin Ichiro
PY - 2004/9
Y1 - 2004/9
N2 - The sonodynamically induced antitumor effect of porfimer sodium (PF) was evaluated on a chemically induced mammary tumor in Sprague-Dawley rats. The timing of 24 h after the administration of PF was chosen for the ultrasonic exposure, based on pharmacokinetic analysis of the PF concentrations in the tumor, plasma, skin and muscle. At a PF dose not less than 2.5 mg/kg and at a free-field ultrasonic intensity not less than 3 W/cm2, the synergistic effect between PF administration and ultrasonic exposure on the tumor growth inhibition was significant. The ultrasonic intensity showed a relatively sharp threshold for the synergistic antitumor effect, which is typical of an ultrasonic effect mediated by acoustic cavitation. These results suggest that PF is a potentially useful as a sonosensitizer for sonodynamic treatment of chemically induced tumors.
AB - The sonodynamically induced antitumor effect of porfimer sodium (PF) was evaluated on a chemically induced mammary tumor in Sprague-Dawley rats. The timing of 24 h after the administration of PF was chosen for the ultrasonic exposure, based on pharmacokinetic analysis of the PF concentrations in the tumor, plasma, skin and muscle. At a PF dose not less than 2.5 mg/kg and at a free-field ultrasonic intensity not less than 3 W/cm2, the synergistic effect between PF administration and ultrasonic exposure on the tumor growth inhibition was significant. The ultrasonic intensity showed a relatively sharp threshold for the synergistic antitumor effect, which is typical of an ultrasonic effect mediated by acoustic cavitation. These results suggest that PF is a potentially useful as a sonosensitizer for sonodynamic treatment of chemically induced tumors.
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U2 - 10.1111/j.1349-7006.2004.tb03259.x
DO - 10.1111/j.1349-7006.2004.tb03259.x
M3 - Article
C2 - 15471564
AN - SCOPUS:5044233893
VL - 95
SP - 765
EP - 769
JO - Cancer Science
JF - Cancer Science
SN - 1347-9032
IS - 9
ER -