Sonodynamic therapy on chemically induced mammary tumor: Pharmacokinetics, tissue distribution and sonodynamically induced antitumor effect of gallium-porphyrin complex ATX-70

Nagahiko Yumita, Nobuo Okuyama, Kazuaki Sasaki, Shin Ichiro Umemura

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)

Abstract

Sonodynamically induced antitumor effect of a gallium porphyrin complex, ATX-70 was evaluated on a chemically induced mammary tumor in Sprague-Dawley rats. The timing of 24 h after the administration of ATX-70 was chosen for ultrasonic exposure, based on pharmacokinetic analysis of ATX-70 concentrations in the tumor, plasma, skin, and muscle. At an ATX-70 dose not less than 2.5 mg/kg and at a free-field ultrasonic intensity not less than 3 W/cm2, the synergistic effect between ATX-70 administration and ultrasonic exposure on the tumor growth inhibition was significant. These results suggest that ATX-70 is a potential sonosensitizer for sonodynamic treatment of spontaneous mammary tumors.

Original languageEnglish
Pages (from-to)891-897
Number of pages7
JournalCancer Chemotherapy and Pharmacology
Volume60
Issue number6
DOIs
Publication statusPublished - 2007 Nov 1

Keywords

  • Antitumor effect
  • Chemically induced mammary tumor
  • Pharmacokinetics
  • Sonodynamic therapy
  • Ultrasound

ASJC Scopus subject areas

  • Oncology
  • Toxicology
  • Pharmacology
  • Cancer Research
  • Pharmacology (medical)

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