Sonodynamic approaches to tumor treatment

S. Umemura, K. Kawabata, N. Sugita, K. Sasaki, N. Yumita

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Acoustic cavitation is known to be induced at a relatively low ultrasonic intensity in a standing wave mode. It was recently found to be induced at a relatively low ultrasonic intensity even in a progressive wave mode through superimposing the second harmonic to the fundamental. Various chemical agents were screened in a standing wave mode, and certain porphyrins and xanthenes were found to be sonodynamically active. Certain xanthenes were also found to reduce the in vivo as well as in vitro cavitation threshold. Significant and marked in vivo antitumor effects were observed with a Ga–porphyrin complex and a rose bengal derivative, respectively, in combination with a second-harmonic superimposition exposure in a progressive wave mode.

Original languageEnglish
Pages (from-to)164-168
Number of pages5
JournalInternational Congress Series
Issue numberC
Publication statusPublished - 2004 Oct 1
Externally publishedYes


  • Acoustic cavitation
  • Antitumor effect
  • Porphyrin
  • Progressive wave
  • Second-harmonic superimposition
  • Standing wave
  • Xanthene

ASJC Scopus subject areas

  • Medicine(all)


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