Sonochemical application of ultrasound to tumor treatment

Shin Ichiro Umemura

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


We recently found that chemical agents such as hematoporphyrin can be activated by ultrasound, producing significant antitumor effects. This was demonstrated with plane wave insonation at 2 MHz in experiments of killing isolated tumor cells. The efficacy of focal ultrasound at 750 kHz to localize sonochemical reactions was also demonstrated in insonation of a specially developed agarose gel phantom and in treatments of inoculated experimental tumors.

Original languageEnglish
Pages (from-to)2846-2851
Number of pages6
JournalJapanese journal of applied physics
Issue number5S
Publication statusPublished - 1994 May
Externally publishedYes


  • Active oxygen
  • Antitumor effect
  • Cavitation
  • Focal ultrasound
  • Hematoporphyrin
  • Sonochemical activation

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)


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