Sonochemical activation of hematoporphyrin: A potential modality for cancer treatment

Shin Ichiro Umemura, Nagahiko Yumita, Ryuichiro Nishigaki, Koshiro Umemura

Research output: Contribution to journalConference articlepeer-review

54 Citations (Scopus)

Abstract

In-vitro and in-vivo studies demonstrate the antitumor effect of hematoporphyrin sonochemically activated by ultrasound irradiation. Tumor cell suspensions with and without hematoporphyrin (Hp) are irradiated by continuous-wave ultrasound. Ultrasound cell damage with Hp is significantly greater than that without Hp, while no cell damage by Hp alone was detected. Growth of tumors implanted in mice is stopped by the ultrasound irradiation after Hp administration. Because the cell-damage enhancement by Hp is suppressed by adding histidine to the suspension but not by adding mannitol, the enhancement is most likely due to sonochemical generation of singlet oxygen.

Original languageEnglish
Pages (from-to)955-960
Number of pages6
JournalUltrasonics Symposium Proceedings
Volume2
Publication statusPublished - 1989 Dec 1
EventIEEE 1989 Ultrasonics Symposium - Montreal, Que, Can
Duration: 1989 Oct 31989 Oct 6

ASJC Scopus subject areas

  • Engineering(all)

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