Somatostatin-secreting pheochromocytoma mimicking insulin-dependent diabetes mellitus

Hiroyuki Hirai, Sanae Midorikawa, Shinichi Suzuki, Hironobu Sasano, Tsuyoshi Watanabe, Hiroaki Satoh

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

We herein present the findings of a 42-year-old woman with either adrenal pheochromocytoma or intraadrenal paraganglioma that simultaneously secreted somatostatin, thus mimicking insulin-dependent diabetes mellitus. Pheochromocytoma was clinically diagnosed based on scintigraphy, elevated catecholamine levels, and finally a histopathological analysis of resected specimens. The patient had diabetic ketosis, requiring 40 U insulin for treatment. Following laparoscopic adrenalectomy, insulin therapy was discontinued and the urinary c-peptide levels changed from 5.5-9.0 to 81.3-87.0 μg/day. Histologically, somatostatin immunoreactivity was detected and the somatostatin levels were elevated in the serum-like fluid obtained from the tumor. Clinicians should be aware of the possible occurrence of simultaneous ectopic hormone secretion in patients with pheochromocytoma.

Original languageEnglish
Pages (from-to)2985-2991
Number of pages7
JournalInternal Medicine
Volume55
Issue number20
DOIs
Publication statusPublished - 2016
Externally publishedYes

Keywords

  • Catecholamine
  • Pheochromocytoma
  • Secondary diabetes
  • Somatostatin
  • Urine c-peptide

ASJC Scopus subject areas

  • Internal Medicine

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