Pd(II)-catalyzed intermolecular 1,2-aminooxygenation and 1,2-oxyamination of conjugated dienes have been developed. The chemoselective preparation of a variety of 2-functionalized and 3-functionalized 1,4-benzoxazine derivatives was accomplished via the adjustment of a coordinating solvent. Oxygen was successfully used in this oxidative difunctionalization of alkenes. Good yields and selectivities were obtained for most products. A product bearing a spiro structure was also obtained from a 2,3-disubstituted-1,3-diene.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry