Abstract
The ginseng tetrapeptide H-L-Val-γ-D-Glu-D-Arg-Gly-OH (1) was synthesized using a solution-phase methodology, and its solution conformation in dimethyl sulfoxide (DMSO)-d6 was determined by a combination of NMR and computational techniques with the DADAS90 program. This compound has a rigid backbone based on three intramolecular hydrogen bonds between D-Arg NH and L- Val CO, between Gly NH and D-Glu CO, and between Gly NH and Gly CO.
Original language | English |
---|---|
Pages (from-to) | 690-692 |
Number of pages | 3 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 46 |
Issue number | 4 |
Publication status | Published - 1998 |
Keywords
- Conformation
- Ginseng tetrapeptide
- Intramolecular hydrogen bond
- NMR
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry
- Chemistry(all)
- Pharmacology