Solution conformation of ginseng tetrapeptide H-L-Val-γ-D-Glu-D-Arg- Gly-OH

Takashi Ishizu, Masako Fujiwara, Akira Yagi, Shunsaku Noguchi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The ginseng tetrapeptide H-L-Val-γ-D-Glu-D-Arg-Gly-OH (1) was synthesized using a solution-phase methodology, and its solution conformation in dimethyl sulfoxide (DMSO)-d6 was determined by a combination of NMR and computational techniques with the DADAS90 program. This compound has a rigid backbone based on three intramolecular hydrogen bonds between D-Arg NH and L- Val CO, between Gly NH and D-Glu CO, and between Gly NH and Gly CO.

Original languageEnglish
Pages (from-to)690-692
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume46
Issue number4
Publication statusPublished - 1998

Keywords

  • Conformation
  • Ginseng tetrapeptide
  • Intramolecular hydrogen bond
  • NMR

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

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