Solubility in and affinity for the bile salt micelle of plant sterols are important determinants of their intestinal absorption in rats

Tadateru Hamada, Hitomi Goto, Takashi Yamahira, Takashi Sugawara, Katsumi Imaizumi, Ikuo Ikeda

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

Intestinal absorption of various plant sterols was investigated in thoracic duct-cannulated normal rats. Lymphatic recovery was the highest in campesterol, intermediate in brassicasterol and sitosterol, and the lowest in stigmasterol and sitostanol. Higher solubility in the bile salt micelle was observed in sitosterol, campesterol, and sitostanol than in brassicasterol and stigmasterol. The solubility of the latter two sterols was extremely low. When the affinity of plant sterols for the bile salt micelle was compared in an in vitro model system, which assessed sterol transfer from the micellar to the oil phase, the transfer rate was the highest in brassicasterol, intermediate in campesterol and stigmasterol, and lowest in sitosterol and sitostanol. Although no significant correlations between lymphatic recovery of plant sterols and their micellar solubility or transfer rate from the bile salt micelle were observed, highly positive correlation was obtained between the lymphatic recovery and the multiplication value of the micellar solubility and the transfer rate. These observations strongly suggest that both solubility in and affinity for the bile salt micelle of plant sterols are important determinants of their intestinal absorption in rats.

Original languageEnglish
Pages (from-to)551-556
Number of pages6
JournalLipids
Volume41
Issue number6
DOIs
Publication statusPublished - 2006 Jun 1

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Cell Biology

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