Solubility estimation of high-value natural products in supercritical CO2 based on solubility parameter

Megumi Sato, Keisuke Takeda, Masaki Ota, Yoshiyuki Sato, Hiroshi Inomata

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Solubilities of flavone and 6-methoxyflavone in supercritical carbon dioxide (SC-CO2) were measured at temperatures ranging from 313 to 333 K and pressures ranging from 10 to 22MPa by a flow type apparatus. The solubilities were determined from ultraviolet-visible spectroscopic analysis of solute concentration of ethanol solution in the trap and the corresponding CO2 amount. Solubility parameters (SP) of solutes were also estimated from correlation with a regular solution model, and these were comparable to the values obtained by solubility measurement using organic solvents under ambient conditions. The method for determining SP of solutes from solubilities in supercritical conditions is expected to be useful for SC-CO2 extraction processing.

Original languageEnglish
Pages (from-to)466-471
Number of pages6
Journalkagaku kogaku ronbunshu
Issue number5
Publication statusPublished - 2010 Nov 9


  • Flavonoids
  • Solubility
  • Solubility parameter
  • Supercritical carbon dioxide

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)


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