Solid state structures of lead complexes with relevance for biological systems

Katsuyuki Aoki, Kazutaka Murayama, Ning Hai Hu

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Structural information on the interaction between lead ion and its targeting biological substances is important not only for enriching coordination chemistry of lead but for successfully treating lead poisoning that is a present-day problem. This chapter provides structural data, mainly metal binding sites/modes, observed in crystal structures of lead complexes with biorelevant molecules, obtained from the Cambridge Structural Database (the CSD version 5.36 updated to May 2015) and the Protein Data Bank (PDB updated to February 2016). Ligands include (i) amino acids and small peptides, (ii) proteins, (iii) nucleic acid constituents, (iv) nucleic acids, (v) simple saccharides, and (vi) other biorelevant molecules involving leaddetoxification agents. For representative complexes of these ligands, some details on the environment of the metal coordination and structural characteristics are described.

Original languageEnglish
Title of host publicationLead
Subtitle of host publicationIts Effects on Environment and Health
PublisherWalter de Gruyter GmbH
Pages123-199
Number of pages77
Volume17
ISBN (Electronic)9783110434330
ISBN (Print)9783110441079
DOIs
Publication statusPublished - 2017 Apr 10

Keywords

  • Amino acids
  • Crystal structures
  • Detoxification agents
  • Lead ion
  • Nucleic acids
  • Peptides
  • Proteins
  • Saccharides
  • Stereochemically active lone pair effect
  • nucleic acid constituents

ASJC Scopus subject areas

  • Chemistry(all)
  • Environmental Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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