Solid pseudopapillary neoplasms of the pancreas: An 18-year experience at a single Japanese Institution

Takanori Morikawa, Tohru Onogawa, Shimpei Maeda, Tatsuyuki Takadate, Keiichi Shirasaki, Hiroshi Yoshida, Kazuyuki Ishida, Fuyuhiko Motoi, Takeshi Naitoh, Toshiki Rikiyama, Yu Katayose, Shinichi Egawa, Michiaki Unno

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Purpose: This study investigated the clinicopathological features and surgical management of solid pseudopapillary neoplasms at a single institution in Japan. Methods: Seventeen patients (the largest series in Japan) those underwent surgery for pathologically confirmed solid pseudopapillary neoplasms were retrospectively reviewed. Results: Sixteen patients were women and their mean age was 34.1years. Most patients were asymptomatic (n=11), and the average tumor diameter was 51.8mm. The most common imaging characteristic was tumors of solid and cystic type (n=10), which were most commonly located in the pancreatic body (n=7). All patients underwent surgical exploration, i.e., distal pancreatectomies in 7 patients (laparoscopically performed in 2); middle pancreatectomies, 4; pancreaticoduodenectomies, 4; enucleation, 1; and liver resection, 1. No surgical mortalities occurred, and postsurgical complications occurred in 9 patients. Four patients had malignant tumors. One patient with liver metastases experienced recurrence, which was well controlled by paclitaxel. The remaining patients were disease free at a median follow-up of 51months. Conclusions: Solid pseudopapillary neoplasms can be treated by complete tumor resection with limited resection or a minimally invasive approach when applicable. The combination of surgical resection and chemotherapy may therefore prolong survival, even in malignant cases.

Original languageEnglish
Pages (from-to)26-32
Number of pages7
JournalSurgery today
Volume43
Issue number1
DOIs
Publication statusPublished - 2013 Jan

Keywords

  • Malignant potential
  • Pancreas
  • Single institution
  • Solid pseudopapillary neoplasm
  • Surgical treatment

ASJC Scopus subject areas

  • Surgery

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