Solid-phase total synthesis of biologically active cyclodepsipeptide spiruchostatin A

Chemistry

• Cyclic Peptide 100%
• Total Synthesis 100%
• Spiruchostatin 66%
• Solid 66%
• Drug Discovery 66%
• Metabolic 33%
• Permeability 33%
• Silyl 33%
• Cyclization Reaction 33%
• Amino-Acid Residue 33%
• Structure-Activity Relationship 33%
• Histone 33%
• Macrolactonization 33%
• Cyclodepsipeptide 33%
• Polymer 33%
• Inhibitor 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Cyclopeptide 100%
• Polymer 33%
• Glycine 33%
• Structure Activity Relationship 33%
• Histone Deacetylase Inhibitor 33%
• Cyclodepsipeptide 33%