Solid-phase synthesis of peptide ribonucleic acids (PRNA)

Hirofumi Sato, Yusuke Hashimoto, Takehiko Wada, Yoshihisa Inoue

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

The range of available peptide ribonucleic acid (PRNA) monomers was fully expanded for the use in solid-phase synthesis of PRNA oligomers, which were designed to reversibly control the recognition and complexation behavior of the complementary DNA/RNA by external factors. A couple of PRNA 12-mers with desired purine-pyrimidine mixed sequences were prepared indeed in high yields by the solid-phase synthesis.

Original languageEnglish
Pages (from-to)7871-7878
Number of pages8
JournalTetrahedron
Volume59
Issue number40
DOIs
Publication statusPublished - 2003 Sep 29
Externally publishedYes

Keywords

  • Homo-uracil
  • L-glutamic acid
  • Peptide

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Solid-phase synthesis of peptide ribonucleic acids (PRNA)'. Together they form a unique fingerprint.

Cite this