A highly simplified synthesis of a tetrasaccharide was possible by a repeated coupling/capture-release cycle. In the first cycle, a glycosyl acceptor (1) bound to a soluble polymer reacted with a glycosyl donor (2) having a chloroacetyl group as a temporary protecting group. Solid-phase capture by a resin-bound thiol group (in 3) was followed by Fmoc removal, which released the polymer-bound disaccharide 4 into the solution phase. Fmoc = 9-fluorenylmethoxycarbonyl.
|Number of pages||4|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - 2001 Dec 17|
- Polymer support
- Solid-phase synthesis
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