Solid phase approach to muscone synthesis: Rh(I)-catalyzed hydroformylation of a 1,1-disubstituted alkene on the Multipin® system

Takashi Takahashi, Satoshi Ebata, Takayuki Doi

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Rh(I)-catalyzed hydroformylation of a polymer-supported 1,1-disubstituted alkene was carried out on the Multipin® system. The reaction proceeded under 75 atm of syngas (H2:CO = 1:1) providing the corresponding aldehyde on the solid support. Optimization of the reaction conditions is described.

Original languageEnglish
Pages (from-to)1369-1372
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number11
DOIs
Publication statusPublished - 1998 Mar 12
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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