Sol-gel synthesis, characterization, and in vitro compatibility of iron nanoparticle-encapsulating silica microspheres for hyperthermia in cancer therapy

Zhixia Li, Masakazu Kawashita, Tada Aki Kudo, Hiroyasu Kanetaka

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We prepared iron nanoparticle-encapsulating silica (FeSi) microspheres and tested their suitability as thermal seeds for hyperthermia in cancer therapy. These microspheres were prepared by introducing a ferric ion (Fe3+) into microspheres of a SiO2 gel matrix derived from the hydrolysis of tetramethoxysilane in a water-in-oil emulsion that was then heat-treated at 850 °C in an argon atmosphere. The particles obtained were 5-30 lm in size and had a saturation magnetization up to 21 emu g-1 and a coercive force of 86-133 Oe. Heat generation in an alternating current magnetic field of 300 Oe at 100 kHz was estimated to be 7.7-28.9 W g-1. The in vitro cell biocompatibility of the microspheres was assessed by culturing rat fibroblast Rat-1 cells in medium supplemented with microspheres containing 6.7 % of iron nanoparticles. At microsphere concentrations of<7.5 g L-1 proliferation of Rat-1 cells was not significantly inhibited.

Original languageEnglish
Pages (from-to)2461-2469
Number of pages9
JournalJournal of Materials Science: Materials in Medicine
Volume23
Issue number10
DOIs
Publication statusPublished - 2012 Oct 1

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Fingerprint Dive into the research topics of 'Sol-gel synthesis, characterization, and in vitro compatibility of iron nanoparticle-encapsulating silica microspheres for hyperthermia in cancer therapy'. Together they form a unique fingerprint.

Cite this