We prepared iron nanoparticle-encapsulating silica (FeSi) microspheres and tested their suitability as thermal seeds for hyperthermia in cancer therapy. These microspheres were prepared by introducing a ferric ion (Fe3+) into microspheres of a SiO2 gel matrix derived from the hydrolysis of tetramethoxysilane in a water-in-oil emulsion that was then heat-treated at 850 °C in an argon atmosphere. The particles obtained were 5-30 lm in size and had a saturation magnetization up to 21 emu g-1 and a coercive force of 86-133 Oe. Heat generation in an alternating current magnetic field of 300 Oe at 100 kHz was estimated to be 7.7-28.9 W g-1. The in vitro cell biocompatibility of the microspheres was assessed by culturing rat fibroblast Rat-1 cells in medium supplemented with microspheres containing 6.7 % of iron nanoparticles. At microsphere concentrations of<7.5 g L-1 proliferation of Rat-1 cells was not significantly inhibited.
|Number of pages||9|
|Journal||Journal of Materials Science: Materials in Medicine|
|Publication status||Published - 2012 Oct 1|
ASJC Scopus subject areas
- Biomedical Engineering