Sodium butyrate inhibits angiogenesis of human intestinal microvascular endothelial cells through COX-2 inhibition

Hitoshi Ogawa, Parvaneh Rafiee, Pamela J. Fisher, Nathan A. Johnson, Mary F. Otterson, David G. Binion

    Research output: Contribution to journalArticlepeer-review

    23 Citations (Scopus)

    Abstract

    We examined the effect of sodium butyrate on in vitro angiogenesis and cyclooxygenase (COX) expression using primary cultures of human intestinal microvascular endothelial cells (HIMEC). Butyrate inhibited VEGF-induced cellular proliferation, transmigration and tube formation of HIMEC. Butyrate also inhibited COX-2 expression as well as prostaglandin (PG)E2 and PGI2 production, and administration of PGI2 analog partially reversed the effect of butyrate on HIMEC angiogenesis. These results indicate that sodium butyrate inhibits HIMEC angiogenesis through down-regulation of COX-2 expression and PG production, and suggest that anti-angiogenic mechanisms may also be involved in the inhibitory effect of sodium butyrate on tumor growth.

    Original languageEnglish
    Pages (from-to)88-94
    Number of pages7
    JournalFEBS Letters
    Volume554
    Issue number1-2
    DOIs
    Publication statusPublished - 2003 Nov 6

    Keywords

    • Angiogenesis
    • Cyclooxygenase-2
    • Human intestinal microvascular endothelial cell
    • Prostaglandin I
    • Sodium butyrate

    ASJC Scopus subject areas

    • Biochemistry
    • Biophysics
    • Molecular Biology

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