SnCl4-promoted ethenylation reaction of hydroxylated heteroarenes

Kensuke Akamatsu, Ryo Amemiya, Masahiko Yamaguchi

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Reaction of hydroxylated heteroarenes and acetylene in the presence of SnCl4 and Bu3N (or Et3N) gives the corresponding ethenylated arenes. The reaction takes place at the neighboring position of the hydroxy group, and is applicable to quinolines, an isoquinoline, pyridines, and N-trifluoromethanesulfonylated indoles provided that the optimized conditions for the ethenylation and workup are employed.

Original languageEnglish
Pages (from-to)1839-1847
Number of pages9
Issue number8
Publication statusPublished - 2004 Aug 1

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry


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