Smooth pursuit eye movements and express saccades in schizophrenic patients

Yoshihiko Matsue, Kazuhito Osakabe, Hidemitsu Saito, Yutaka Goto, Takashi Ueno, Hiroo Matsuoka, Hideaki Chiba, Yuji Fuse, Mitsumoto Sato

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Abnormalities of saccades such as disinhibition have been hypothesized as one cause of smooth pursuit eye movement (SPEM) dysfunctions in schizophrenia. Thus, we studied saccadic eye movements in schizophrenics with SPEM dysfunction. Subjects were divided into three groups: 10 normal control subjects, 10 schizophrenic subjects without SPEM dysfunction and 10 schizophrenic subjects with SPEM dysfunction characterized by a cogwheel appearance. Visually guided saccades in gap and overlap paradigms (Saslow, 1967) were examined and saccadic reaction times (SRTs) were measured in all subjects. Only schizophrenics with SPEM dysfunctions tended to manifest exessive reflexive saccades, named express saccades (Fischer, 1987), in the gap paradigm. Moreover, most of them were also found to have express saccades in the overlap paradigm, whereas normal subjects and schizophrenic subjects without SPEM dysfunction did not show such phenomena under the same conditions. In particular, most express saccades in the overlap paradigm in schizophrenics with SPEM dysfunction, were found in movements to the right.

Original languageEnglish
Pages (from-to)121-130
Number of pages10
JournalSchizophrenia Research
Volume12
Issue number2
DOIs
Publication statusPublished - 1994 Jan 1

Keywords

  • (Schizophrenia)
  • Express saccade
  • Left hemisphere
  • Smooth pursuit eye movement
  • Visually guided saccade

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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