Abstract
Chemical modification in the hydrophilic and hydrophobic regions of leukotrienes was investigated in relation to their smooth muscle contractile activities. The conjugated diene or triene moiety in the hydrophobic region is crucial for potent contractile activity. The hydrophilic region at the C-6 position is not dependent only on amino acid or peptide for potent contractile activity; some heterocyclic comnounds can be used instead.
| Original language | English |
|---|---|
| Pages (from-to) | 3326-3329 |
| Number of pages | 4 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 31 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 1983 Jan 1 |
Keywords
- contractile activity
- guinea pig trachea
- guinea pigileum
- leukotriene C4
- leukotriene D4
- leukotriene analogue
- slow reacting substance
- smooth muscle
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery
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Cite this
Cho, H., Ueda, M., Funahashi, K., & Koda, K. (1983). Smooth Muscle Contractile Activities of Leukotriene Analogues. Chemical and Pharmaceutical Bulletin, 31(9), 3326-3329. https://doi.org/10.1248/cpb.31.3326