Smooth Muscle Contractile Activities of Leukotriene Analogues

Hidetsura Cho; Masaru Ueda; Kazuteru Funahashi; Keiko Koda

doi:10.1248/cpb.31.3326

Smooth Muscle Contractile Activities of Leukotriene Analogues

Hidetsura Cho, Masaru Ueda, Kazuteru Funahashi, Keiko Koda

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Chemical modification in the hydrophilic and hydrophobic regions of leukotrienes was investigated in relation to their smooth muscle contractile activities. The conjugated diene or triene moiety in the hydrophobic region is crucial for potent contractile activity. The hydrophilic region at the C-6 position is not dependent only on amino acid or peptide for potent contractile activity; some heterocyclic comnounds can be used instead.

Original language	English
Pages (from-to)	3326-3329
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	31
Issue number	9
DOIs	https://doi.org/10.1248/cpb.31.3326
Publication status	Published - 1983 Jan 1

Keywords

contractile activity
guinea pig trachea
guinea pigileum
leukotriene C4
leukotriene D4
leukotriene analogue
slow reacting substance
smooth muscle

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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AU - Cho, Hidetsura

AU - Ueda, Masaru

AU - Funahashi, Kazuteru

AU - Koda, Keiko

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Y1 - 1983/1/1

N2 - Chemical modification in the hydrophilic and hydrophobic regions of leukotrienes was investigated in relation to their smooth muscle contractile activities. The conjugated diene or triene moiety in the hydrophobic region is crucial for potent contractile activity. The hydrophilic region at the C-6 position is not dependent only on amino acid or peptide for potent contractile activity; some heterocyclic comnounds can be used instead.

AB - Chemical modification in the hydrophilic and hydrophobic regions of leukotrienes was investigated in relation to their smooth muscle contractile activities. The conjugated diene or triene moiety in the hydrophobic region is crucial for potent contractile activity. The hydrophilic region at the C-6 position is not dependent only on amino acid or peptide for potent contractile activity; some heterocyclic comnounds can be used instead.

KW - contractile activity

KW - guinea pig trachea

KW - guinea pigileum

KW - leukotriene C4

KW - leukotriene D4

KW - leukotriene analogue

KW - slow reacting substance

KW - smooth muscle

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JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

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Smooth Muscle Contractile Activities of Leukotriene Analogues

Abstract

Keywords

ASJC Scopus subject areas

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