Smooth Muscle Contractile Activities of Leukotriene Analogues

Hidetsura Cho, Masaru Ueda, Kazuteru Funahashi, Keiko Koda

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Chemical modification in the hydrophilic and hydrophobic regions of leukotrienes was investigated in relation to their smooth muscle contractile activities. The conjugated diene or triene moiety in the hydrophobic region is crucial for potent contractile activity. The hydrophilic region at the C-6 position is not dependent only on amino acid or peptide for potent contractile activity; some heterocyclic comnounds can be used instead.

Original languageEnglish
Pages (from-to)3326-3329
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume31
Issue number9
DOIs
Publication statusPublished - 1983 Jan 1

Keywords

  • contractile activity
  • guinea pig trachea
  • guinea pigileum
  • leukotriene C4
  • leukotriene D4
  • leukotriene analogue
  • slow reacting substance
  • smooth muscle

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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