TY - JOUR
T1 - Smoking and pancreatic cancer incidence
T2 - A pooled analysis of 10 population-based cohort studies in Japan
AU - Koyanagi, Yuriko N.
AU - Ito, Hidemi
AU - Matsuo, Keitaro
AU - Sugawara, Yumi
AU - Hidaka, Akihisa
AU - Sawada, Norie
AU - Wada, Keiko
AU - Nagata, Chisato
AU - Tamakoshi, Akiko
AU - Lin, Yingsong
AU - Takeuchi, Taro
AU - Kitamura, Yuri
AU - Utada, Mai
AU - Sadakane, Atsuko
AU - Mizoue, Tetsuya
AU - Naito, Mariko
AU - Tanaka, Keitaro
AU - Shimazu, Taichi
AU - Tsugane, Shoichiro
AU - Inoue, Manami
N1 - Funding Information:
This study was supported by the National Cancer Center Research and Development Fund (30-A-15, 27-A-4), National Cancer Center, Tokyo, Japan.
Publisher Copyright:
© 2019 The Authors.
PY - 2019
Y1 - 2019
N2 - Background: Detailed prospective evaluation of cigarette smoking associated with pancreatic cancer risk in large Asian populations is limited. The aim of this study was to examine this association in a Japanese population, with a particular focus on evaluating sex differences. Methods: We performed a pooled analysis of 10 populationbased cohort studies. We calculated study-specific HRs and 95% confidence intervals (CI) using Cox proportional hazards regression, and then estimated summary HRs by pooling these estimates with a random effects model. Results: During 4,695,593 person-years of follow-up in 354,154 participants, 1,779 incident pancreatic cancer cases were identified. We observed an increased pancreatic cancer risk for current smoking compared with never smoking in both males [HR (95% CI), 1.59 (1.32-1.91)] and females [HR (95% CI), 1.81 (1.43-2.30)]. Significant risk elevations for former smoking and small cumulative dose of -20 pack-years (PY) were observed only among females, regardless of environmental tobacco smoke exposure. Trend analysis indicated significant 6% and nonsignificant 6% increases in pancreatic cancer risk for every 10 PYs in males and females, respectively. Risk became comparable with never smokers after 5 years of smoking cessation in males. In females, however, we observed no risk attenuation by smoking cessation. Conclusions: This study supports the well-known association between smoking and pancreatic cancer and indicates potential sex differences in a Japanese population. Quitting smoking would be beneficial for pancreatic cancer prevention, especially in males. Impact: Pancreatic cancer risk is increased with cumulative smoking exposure and decreased with smoking cessation, with potential sex differences.
AB - Background: Detailed prospective evaluation of cigarette smoking associated with pancreatic cancer risk in large Asian populations is limited. The aim of this study was to examine this association in a Japanese population, with a particular focus on evaluating sex differences. Methods: We performed a pooled analysis of 10 populationbased cohort studies. We calculated study-specific HRs and 95% confidence intervals (CI) using Cox proportional hazards regression, and then estimated summary HRs by pooling these estimates with a random effects model. Results: During 4,695,593 person-years of follow-up in 354,154 participants, 1,779 incident pancreatic cancer cases were identified. We observed an increased pancreatic cancer risk for current smoking compared with never smoking in both males [HR (95% CI), 1.59 (1.32-1.91)] and females [HR (95% CI), 1.81 (1.43-2.30)]. Significant risk elevations for former smoking and small cumulative dose of -20 pack-years (PY) were observed only among females, regardless of environmental tobacco smoke exposure. Trend analysis indicated significant 6% and nonsignificant 6% increases in pancreatic cancer risk for every 10 PYs in males and females, respectively. Risk became comparable with never smokers after 5 years of smoking cessation in males. In females, however, we observed no risk attenuation by smoking cessation. Conclusions: This study supports the well-known association between smoking and pancreatic cancer and indicates potential sex differences in a Japanese population. Quitting smoking would be beneficial for pancreatic cancer prevention, especially in males. Impact: Pancreatic cancer risk is increased with cumulative smoking exposure and decreased with smoking cessation, with potential sex differences.
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U2 - 10.1158/1055-9965.EPI-18-1327
DO - 10.1158/1055-9965.EPI-18-1327
M3 - Article
C2 - 31113869
AN - SCOPUS:85070618859
VL - 28
SP - 1370
EP - 1378
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
SN - 1055-9965
IS - 8
ER -