Small open reading frames in 5′ untranslated regions of mRNAs

Riu Yamashita, Yutaka Suzuki, Kenta Nakai, Sumio Sugano

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Using the 5′-end sequence data from 'oligo-capped' cDNAs, we generated a representative full-length cDNA dataset for 4870 RefSeq entries, and analyzed the 5′ untranslated region (UTR) of these genes. To our surprise, about half of the 4870 genes had an upstream ATG before the ATG that starts the longest open reading frame (ORF), suggesting that about half of them have small ORFs in their 5′ UTR of average length of 31 amino acids. They require attention for further analysis to identify their biological role.

Original languageEnglish
Pages (from-to)987-991
Number of pages5
JournalComptes Rendus - Biologies
Volume326
Issue number10-11
DOIs
Publication statusPublished - 2003

Keywords

  • Cap
  • Full-length cDNA
  • House keeping genes
  • Open reading frame
  • Transcriptional start site
  • Untranslated region

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)

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