Small molecule-PNA oligomer conjugates for rRNA A-site at neutral pH for FID assays

En Ting Tabitha Lee, Yusuke Sato, Seiichi Nishizawa

Research output: Contribution to journalArticlepeer-review

Abstract

A triplex-forming PNA oligomer conjugated with a naphthyridine derivative (ATMND-C2-NH2) showed high selectivity and strong binding for the bacterial rRNA A-site at pH 7.0 (Kd = 190 ± 72 nM), which was accompanied by fluorogenic signaling that allowed the potential use of this conjugate probe in fluorescent indicator displacement assays. This journal is

Original languageEnglish
Pages (from-to)14976-14979
Number of pages4
JournalChemical Communications
Volume56
Issue number95
DOIs
Publication statusPublished - 2020 Dec 11

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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