Small molecule-PNA oligomer conjugates for rRNA A-site at neutral pH for FID assays

En Ting Tabitha Lee; Yusuke Sato; Seiichi Nishizawa

doi:10.1039/d0cc06084d

Small molecule-PNA oligomer conjugates for rRNA A-site at neutral pH for FID assays

En Ting Tabitha Lee, Yusuke Sato, Seiichi Nishizawa

SCI - Chemistry

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

A triplex-forming PNA oligomer conjugated with a naphthyridine derivative (ATMND-C2-NH2) showed high selectivity and strong binding for the bacterial rRNA A-site at pH 7.0 (Kd = 190 ± 72 nM), which was accompanied by fluorogenic signaling that allowed the potential use of this conjugate probe in fluorescent indicator displacement assays. This journal is

Original language	English
Pages (from-to)	14976-14979
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	95
DOIs	https://doi.org/10.1039/d0cc06084d
Publication status	Published - 2020 Dec 11

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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author = "Lee, {En Ting Tabitha} and Yusuke Sato and Seiichi Nishizawa",

note = "Funding Information: This work was supported by Grant-in-Aid for Scientific Research (B) (20H02761) from Japan Society for the Promotion of Science (JSPS). Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

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AU - Lee, En Ting Tabitha

AU - Sato, Yusuke

AU - Nishizawa, Seiichi

N1 - Funding Information: This work was supported by Grant-in-Aid for Scientific Research (B) (20H02761) from Japan Society for the Promotion of Science (JSPS). Publisher Copyright: © The Royal Society of Chemistry.

PY - 2020/12/11

Y1 - 2020/12/11

N2 - A triplex-forming PNA oligomer conjugated with a naphthyridine derivative (ATMND-C2-NH2) showed high selectivity and strong binding for the bacterial rRNA A-site at pH 7.0 (Kd = 190 ± 72 nM), which was accompanied by fluorogenic signaling that allowed the potential use of this conjugate probe in fluorescent indicator displacement assays. This journal is

AB - A triplex-forming PNA oligomer conjugated with a naphthyridine derivative (ATMND-C2-NH2) showed high selectivity and strong binding for the bacterial rRNA A-site at pH 7.0 (Kd = 190 ± 72 nM), which was accompanied by fluorogenic signaling that allowed the potential use of this conjugate probe in fluorescent indicator displacement assays. This journal is

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Small molecule-PNA oligomer conjugates for rRNA A-site at neutral pH for FID assays

Abstract

ASJC Scopus subject areas

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