Abstract
A triplex-forming PNA oligomer conjugated with a naphthyridine derivative (ATMND-C2-NH2) showed high selectivity and strong binding for the bacterial rRNA A-site at pH 7.0 (Kd = 190 ± 72 nM), which was accompanied by fluorogenic signaling that allowed the potential use of this conjugate probe in fluorescent indicator displacement assays. This journal is
Original language | English |
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Pages (from-to) | 14976-14979 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 56 |
Issue number | 95 |
DOIs | |
Publication status | Published - 2020 Dec 11 |
ASJC Scopus subject areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Chemistry(all)
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry