TY - JOUR
T1 - Small-molecule microarrays as tools for facilitating chemical genomics
T2 - Recent advances
AU - Kanoh, Naoki
AU - Osada, Hiroyuki
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2006/6
Y1 - 2006/6
N2 - The identification of small molecule ligands for cellular proteins of biologically importance has not only provided new insights in biology, but has also provided organic chemists with the opportunity to create new synthetic molecules which efficiently regulate specific protein-protein interactions and biological processes. Small-molecule microarrays are recently developed as platforms to screen such small molecule ligands for proteins of interest. The small-molecule microarray technology is highly dependent on chemistry to immobilize small molecules on a variety of solid surfaces, and synthetic organic chemistry will continue to play a significant role in this field. This review covers the recent advances in the field with particular emphasis on the immobilization chemistry, as well as technical advances in the platform optimization and the successful applications of this platform.
AB - The identification of small molecule ligands for cellular proteins of biologically importance has not only provided new insights in biology, but has also provided organic chemists with the opportunity to create new synthetic molecules which efficiently regulate specific protein-protein interactions and biological processes. Small-molecule microarrays are recently developed as platforms to screen such small molecule ligands for proteins of interest. The small-molecule microarray technology is highly dependent on chemistry to immobilize small molecules on a variety of solid surfaces, and synthetic organic chemistry will continue to play a significant role in this field. This review covers the recent advances in the field with particular emphasis on the immobilization chemistry, as well as technical advances in the platform optimization and the successful applications of this platform.
KW - Chemical genetics
KW - Chemical genomics
KW - High-throughput screening
KW - Immobilization
KW - Small-molecule ligand
KW - Small-molecule microarrays
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U2 - 10.5059/yukigoseikyokaishi.64.639
DO - 10.5059/yukigoseikyokaishi.64.639
M3 - Article
AN - SCOPUS:33747639898
VL - 64
SP - 639
EP - 650
JO - Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
JF - Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
SN - 0037-9980
IS - 6
ER -