TY - JOUR
T1 - Small molecule delivery using carbon nano-test-tubes
AU - Ittisanronnachai, Somlak
AU - Orikasa, Hironori
AU - Inokuma, Nobuhiro
AU - Uozu, Yoshihiro
AU - Kyotani, Takashi
N1 - Funding Information:
This research was partially supported by Japan Society for the Promotion of Science (JSPS), Grant-in-Aid for Creative Scientific Research, 18651066.
PY - 2008/8
Y1 - 2008/8
N2 - A dye, as a model for small molecular drug, was inserted into carbon nano test tubes (35 nm in diameter, 4.5 μm in length) synthesized using nanochannels of an anodic aluminum oxide film as a template, and the open mouths of the test tubes were sealed by polystyrene polymer. The resulting test tubes are dispersible in water, and the dye remains in the cavities because of the sealing. When the polymer-plug was dissolved by putting the test tubes into good solvents for polystyrene, the dye diffused out from the tube cavities. This study demonstrated the potential use of the test tubes as nano-sized carriers for drug and gene delivery.
AB - A dye, as a model for small molecular drug, was inserted into carbon nano test tubes (35 nm in diameter, 4.5 μm in length) synthesized using nanochannels of an anodic aluminum oxide film as a template, and the open mouths of the test tubes were sealed by polystyrene polymer. The resulting test tubes are dispersible in water, and the dye remains in the cavities because of the sealing. When the polymer-plug was dissolved by putting the test tubes into good solvents for polystyrene, the dye diffused out from the tube cavities. This study demonstrated the potential use of the test tubes as nano-sized carriers for drug and gene delivery.
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U2 - 10.1016/j.carbon.2008.05.013
DO - 10.1016/j.carbon.2008.05.013
M3 - Letter
AN - SCOPUS:47149112538
VL - 46
SP - 1361
EP - 1363
JO - Carbon
JF - Carbon
SN - 0008-6223
IS - 10
ER -