Small-molecular, non-peptide, non-ATP-competitive polo-like kinase 1 (Plk1) inhibitors with a terphenyl skeleton

Yusuke Mita, Tomomi Noguchi-Yachide, Minoru Ishikawa, Yuichi Hashimoto

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Polo-like kinase (Plk) 1 is a serine-threonine protein kinase that plays a role in cell division, and its overexpression is highly correlated with aggressiveness and prognosis of many cancers. We have designed, synthesized and evaluated a series of terphenyl compounds as inhibitors of the kinase activity of Plk1. Some of them act as non-ATP-competitive Plk1 inhibitors.

Original languageEnglish
Pages (from-to)608-617
Number of pages10
JournalBioorganic and Medicinal Chemistry
Volume21
Issue number3
DOIs
Publication statusPublished - 2013 Feb 1
Externally publishedYes

Keywords

  • Inhibitor
  • Non-ATP-competitive
  • Non-peptide
  • Polo-like kinase
  • Small molecule
  • Terphenyl skeleton

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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