Small GTPase Rab2B and Its specific binding protein golgiassociated rab2b interactor-like 4 (GARI-l4) regulate golgi morphology

Megumi Aizawa, Mitsunori Fukuda

    Research output: Contribution to journalArticlepeer-review

    27 Citations (Scopus)

    Abstract

    Background: Rab small GTPases are membrane trafficking proteins in eukaryotes. Results: Comprehensive knockdown screening identified six Rab isoforms that are involved in regulating Golgi morphology in HeLa-S3 cells. Conclusion: Five of the six Rabs, including Rab2A and Rab2B, non-redundantly regulate Golgi morphology. A Rab2B-specific effector, GARI-L4, also regulates it. Significance: This is the first study to systematically analyze all human Rabs in the Golgi.

    Original languageEnglish
    Pages (from-to)22250-22261
    Number of pages12
    JournalJournal of Biological Chemistry
    Volume290
    Issue number36
    DOIs
    Publication statusPublished - 2015 Sep 4

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Cell Biology

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