Small cell lung cancer and progressive retinopathy

Mami Morita, Tatsuro Fukuhara, Hidetoshi Takahashi, Makoto Maemondo

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6 Citations (Scopus)

Abstract

Cancer-associated retinopathy (CAR) is one of the paraneoplastic neurological syndromes and characterised by retinal degeneration. Autoimmunity between cancer cells and retinal proteins is considered a major cause of CAR. The presence of serum autoantibodies to retinal antigens plays an important role in the diagnosis. A 60-year-old man reporting of visual disturbance and paresthaesia of extremities presented to our hospital. CT scan revealed a massive tumour in the left lower lobe of the lung. Small cell lung cancer was diagnosed histologically with bronchoscopy. Ophthalmological examination showed retinopathy but not optic neuritis. Anti-CV2/collapsin response mediator protein (CRMP)-5 and anti-Hu antibodies were detected by further serum examination. It has been reported that anti-CV2/CRMP5 antibodies are present in patients with neoplasms accompanied by retinopathy as well as optic neuritis. This is the first case of CAR with presence of anti-CV2/CRMP5 antibodies without neuritis.

Original languageEnglish
JournalBMJ case reports
Volume2014
DOIs
Publication statusPublished - 2014 Nov 24

ASJC Scopus subject areas

  • Medicine(all)

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    Morita, M., Fukuhara, T., Takahashi, H., & Maemondo, M. (2014). Small cell lung cancer and progressive retinopathy. BMJ case reports, 2014. https://doi.org/10.1136/bcr-2014-205888