Small-angle neutron scattering study of recombinant yeast-derived human hepatitis B virus surface antigen vaccine particle

M. Sato, Y. Ito, K. Kameyama, M. Imai, N. Ishikawa, T. Takagi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The overall and internal structure of recombinant yeast-derived human hepatitis B virus surface antigen vaccine particles was investigated by small-angle neutron scattering using the contrast variation method. The vaccine is a nearly spherical particle, and its contrast-matching point was determined to be at about 24% D2O content, indicating that a large part of the vaccine particle is occupied by lipids and carbohydrates from the yeast. The Stuhrmann plot suggests that the surface antigens exist predominantly in the peripheral region of the particle, which is favorable to the induction of anti-virus antibodies.

Original languageEnglish
Pages (from-to)757-759
Number of pages3
JournalPhysica B: Physics of Condensed Matter
Volume213-214
Issue numberC
DOIs
Publication statusPublished - 1995 Aug 1

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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