Slow fluctuations of single unit activities of hippocampal and thalamic neurons in cats. II. Role of serotonin on the stability of neuronal activities

Tohru Kodama, Hajime Mushiake, Keisetsu Shima, Hayashi Takashi, Mitsuaki Yamamoto

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A series of experiments was carried out both in the hippocampal pyramidal and thalamic ventrobasal neurons to investigate the effect of serotonin level in the brain on slow fluctuations of neuronal discharges. Single neuronal activities were recorded in the following two pharmacologically treated states: (1) a 5-hydroxytryptamine depled state by p-chlorophenylalanine administration (PCPA phase) and (2) a 5-methoxy-N,N-dimethyltryptamine administered state under the PCPA pretreatment (5-MeODMT phase). The slow fluctuations of neuronal activities in the frequency range of 0.02-1.0 Hz in both nuclei were prominent during the PCPA phase and were similar to those during the paradoxical sleep. In contrast, slow fluctuations were suppressed during the 5-MeODMT phase and neuronal activities during this phase were similar to those during slow wave sleep (SWS). The results show that serotonin in the brain definitely plays a role in stabilizing single neuronal activities.

Original languageEnglish
Pages (from-to)35-44
Number of pages10
JournalBrain research
Volume487
Issue number1
DOIs
Publication statusPublished - 1989 May 15

Keywords

  • 1/f Fluctuation
  • 5-Methoxy-N,N-dimethyltryptamine
  • Hippocampus
  • Serotonin
  • Single unit activity
  • Ventrobasal complex
  • p-Chlorophenylalanine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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