SL/Kh strain of mice: A model of spontaneous pre-B-lymphomas

Masako O. Shimada, Yoshihiro Yamada, Yukari Nakakuki, Keisei Okamoto, Manabu Fukumoto, Tasuku Honjo, Hiroshi Hiai

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The SL/Kh strain of mice spontaneously develop two types of non-thymic lymphomas at a high incidence and very short latency. The major type of lymphomas induce systemic lymph node enlargement and hepatosplenomegaly, and the minor type, proliferation predominantly in bone marrow often associated with spinal paralysis. Phenotypes of both types of lymphomas are indistinguishable: they express B220, 6C3, c-kit but not Thy-1.1, Mac-1 and surface Ig. In both types of lymphomas, the immunoglobulin heavy chain gene is found clonally rearranged in the order of VH-D-JH, whereas the light chain gene remains in germ line configuration. About half of the primary lymphomas are dual or oligoclonal in origin. R-PCR also demonstrates expression of lambda 5, RAG-1 and RAG-2, which are specifically associated with pre-B stage lymphocytes. All these observations indicate that both types of the SL/Kh lymphomas are pre-B-lymphomas.

Original languageEnglish
Pages (from-to)573-578
Number of pages6
JournalLeukemia Research
Volume17
Issue number7
DOIs
Publication statusPublished - 1993 Jan 1

Keywords

  • B-cell differentiation
  • animal model
  • pre-B-lymphoma
  • spontaneous tumors

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'SL/Kh strain of mice: A model of spontaneous pre-B-lymphomas'. Together they form a unique fingerprint.

  • Cite this

    Shimada, M. O., Yamada, Y., Nakakuki, Y., Okamoto, K., Fukumoto, M., Honjo, T., & Hiai, H. (1993). SL/Kh strain of mice: A model of spontaneous pre-B-lymphomas. Leukemia Research, 17(7), 573-578. https://doi.org/10.1016/0145-2126(93)90087-2