TY - JOUR
T1 - Skp2 is a promising therapeutic target in breast cancer
AU - Wang, Zhiwei
AU - Fukushima, Hidefumi
AU - Inuzuka, Hiroyuki
AU - Wan, Lixin
AU - Liu, Pengda
AU - Gao, Daming
AU - Sarkar, Fazlul H.
AU - Wei, Wenyi
PY - 2012
Y1 - 2012
N2 - Breast cancer is the most common type of cancer among American women, and remains the second leading cause of cancer-related death for female in the United States. It has been known that several signaling pathways and various factors play critical roles in the development and progression of breast cancer, such as estrogen receptor, Notch, PTEN, human epidermal growth factor receptor 2, PI3K/Akt, BRCA1, and BRCA2. Emerging evidence has shown that the F-box protein S-phase kinase associated protein 2 (Skp2) also plays an important role in the pathogenesis of breast cancer. Therefore, in this brief review, we summarize the novel functions of Skp2 in the pathogenesis of breast cancer. Moreover, we provide further evidence regarding the state of our knowledge toward the development of novel Skp2 inhibitors especially natural "chemopreventive agents" as targeted approach for the prevention and/or treatment of breast cancer.
AB - Breast cancer is the most common type of cancer among American women, and remains the second leading cause of cancer-related death for female in the United States. It has been known that several signaling pathways and various factors play critical roles in the development and progression of breast cancer, such as estrogen receptor, Notch, PTEN, human epidermal growth factor receptor 2, PI3K/Akt, BRCA1, and BRCA2. Emerging evidence has shown that the F-box protein S-phase kinase associated protein 2 (Skp2) also plays an important role in the pathogenesis of breast cancer. Therefore, in this brief review, we summarize the novel functions of Skp2 in the pathogenesis of breast cancer. Moreover, we provide further evidence regarding the state of our knowledge toward the development of novel Skp2 inhibitors especially natural "chemopreventive agents" as targeted approach for the prevention and/or treatment of breast cancer.
KW - Breast cancer
KW - Cell cycle
KW - Signaling pathway
KW - Skp2
KW - Therapy
KW - Ubiquitination
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U2 - 10.3389/fonc.2011.00057
DO - 10.3389/fonc.2011.00057
M3 - Review article
AN - SCOPUS:84866854512
VL - 1
JO - Frontiers in Oncology
JF - Frontiers in Oncology
SN - 2234-943X
IS - JAN
M1 - 00057
ER -