@inproceedings{72a06b00afcf4db7a734fa7e02e5aaf3,
title = "Skeletal muscle tissue improvement by co-culture system in gelatin methacrylate hydrogel",
abstract = "In this study, we demonstrate that a co-culture approach between C2C12 myoblasts and pheochromocytoma PC12 neuronal cells allows for better formation of muscle-like tissues than a mono-culture of C2C12 cells. In particular, we used a micromolding technique to fabricate microgrooved patterns of methacrylated gelatin (GelMA) hydrogel, which served as a substrate to culture encapsulated cells in GelMA and to induce myoblasts alignment. GelMA is a semi-natural polymer that is easy to pattern by UV irradiation for making 3D structures in which cells can proliferate. Myoblasts and the resulting myotubes were analyzed in terms of alignment and length, respectively, in the mono-culture and the co-culture systems for both patterned and unpatterned regions.",
keywords = "C2C12, Co-culture, Gelma, Hydrogel, PC12",
author = "S. Ostrovidov and S. Ahadian and H. Kaji and M. Ramalingam and A. Khademhosseini",
year = "2012",
language = "English",
isbn = "9780979806452",
series = "Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012",
publisher = "Chemical and Biological Microsystems Society",
pages = "1135--1137",
booktitle = "Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012",
note = "16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 ; Conference date: 28-10-2012 Through 01-11-2012",
}