Skeletal diversity by allylation/RCM on Ugi four-component coupling reaction products

Masato Oikawa, Shinya Naito, Makoto Sasaki

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Here, we report a diversity-oriented synthetic approach toward skeletally diverse, cyclized peptidomimetics with diverse appendages. Starting from α-(N-acylamino)amides with various appendages, 12 to 16-membered lactams with defined olefin geometry were synthesized by a common synthetic sequence. We also synthesized the macrocycle in a liquid phase directed toward a construction of the peptidomimetics library.

Original languageEnglish
Pages (from-to)4763-4767
Number of pages5
JournalTetrahedron Letters
Volume47
Issue number27
DOIs
Publication statusPublished - 2006 Jul 3

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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