Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis

Hiroki Inoue, Yuuki Hiradate, Yoshiki Shirakata, Kenta Kanai, Keita Kosaka, Aina Gotoh, Yasuhiro Fukuda, Yutaka Nakai, Takafumi Uchida, Eimei Sato, Kentaro Tanemura

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Tau is one of the microtubule-associated proteins and a major component of paired helical filaments, a hallmark of Alzheimer's disease. Its expression has also been indicated in the testis. However, its function and modification in the testis have not been established. Here, we analyzed the dynamics of phosphorylation patterns during spermatogenesis. The expression of Tau protein and its phosphorylation were shown in the mouse testis. Immunohistochemistry revealed that the phosphorylation was strongly detected during meiosis. Correspondingly, the expression of acetylated tubulin was inversely weakened during meiosis. These results suggest that phosphorylation of Tau protein contributes to spermatogenesis, especially in meiosis.

Original languageEnglish
Pages (from-to)2003-2008
Number of pages6
JournalFEBS Letters
Volume588
Issue number11
DOIs
Publication statusPublished - 2014 May 29

Keywords

  • Meiosis
  • Spermatogenesis
  • Tau
  • Testis

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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