Site-directed alkylation to cytidine within duplex by the oligonucleotides containing functional nucleobases

Fumi Nagatsugi, Takeshi Kawasaki, Natsuko Tokuda, Minoru Maeda, Shigeki Sasaki

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We have previously described that oligonucleotides (ODN) containing phenylsulfoxide derivative of 2-amino-6-vinylpurine nucleoside analog (1) are activated within duplex to form cross-link toward cytidine selectively at the target site. In this paper, we wish to report the search for more stable precursor susceptible for activation within duplex.

Original languageEnglish
Pages (from-to)915-919
Number of pages5
JournalNucleosides, Nucleotides and Nucleic Acids
Volume20
Issue number4-7
DOIs
Publication statusPublished - 2001 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Genetics

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