SIRS (systemic inflammatory response syndrome): clinical entity, definitions, and the significance

S. Kushimoto, Y. Yamamoto

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The clinical entity, definitions, and the significance of SIRS (systemic inflammatory response syndrome) were reviewed. The term, SIRS was proposed to define sepsis and its sequelae clearly in 1991, in order to make early detection of the disease possible, and to improve the ability to compare innovative potential diagnostic and therapeutic modalities by standardizing terms. Although the criteria of SIRS is not strict and too sensitive, SIRS has been shown to be useful as a warning sign of severe condition in clinical setting. We also discussed about a new concept, CARS (compensatory anti-inflammatory response syndrome), which was characterized as anti-inflammatory mediators-dominant condition, in this issue.

Original languageEnglish
Pages (from-to)227-235
Number of pages9
JournalNippon rinsho. Japanese journal of clinical medicine
Volume57
Issue number1
Publication statusPublished - 1999 Jan
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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