SIRS-associated coagulopathy and organ dysfunction in critically ill patients with thrombocytopenia

Hiroshi Ogura, Satoshi Gando, Toshiaki Iba, Yutaka Eguchi, Yasuhiro Ohtomo, Kohji Okamoto, Kazuhide Koseki, Toshihiko Mayumi, Atsuo Murata, Toshiaki Ikeda, Hiroyasu Ishikura, Masashi Ueyama, Shigeki Kushimoto, Daizoh Saitoh, Shigeatsu Endo, Shuji Shimazaki

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Backgrounds: Coagulopathy and thrombocytopenia often occur in critically ill patients, and disseminated intravascular coagulation (DIC) can lead to multiple organ dysfunction and a poor outcome. However, the relation between coagulopathy and systemic inflammatory response has not been thoroughly clarified. Thus, we evaluated coagulative activity, organ dysfunction, and systemic inflammatory response syndrome (SIRS) in critically ill patients with thrombocytopenia and examined the balance between coagulopathy and systemic inflammation. Patients and Methods: Two hundred seventy-three patients, who were admitted to 13 critical care centers in Japan and fulfilled the criteria of platelet count of less than 150·10/L, were included. Coagulative variables (platelet count, fibrin/fibrinogen degradation products, and DIC scores), organ dysfunction index (Sequential Organ Failure Assessment [SOFA] score), and SIRS score in each patient were evaluated for 4 consecutive days after fulfilling the above entry criteria. The effect of SIRS on coagulopathy and organ dysfunction was evaluated in these patients. Results: Both the maximum SIRS score and entry SIRS score had significant relation to the maximum SOFA score during the observation period. Coagulation disorders indicated by the minimum platelet count, maximum DIC scores, and positivity for DIC worsened gradually with increases in SIRS scores. Both the minimum platelet count and maximum DIC scores were significantly correlated with the maximum SOFA score, indicating that a relation exists between coagulopathy and organ dysfunction. Conclusions: In critically ill patients with thrombocytopenia, coagulopathy and organ dysfunction progress with significant mutual correlation, depending on the increase in SIRS scores. The SIRS-associated coagulopathy may play a critical role in inducing organ dysfunction after severe insult.

Original languageEnglish
Pages (from-to)411-417
Number of pages7
JournalShock
Volume28
Issue number4
DOIs
Publication statusPublished - 2007 Oct

Keywords

  • Disseminated intravascular coagulation
  • Multiple organ dysfunction syndrome
  • Platelet
  • SOFA score
  • Systemic inflammation

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

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    Ogura, H., Gando, S., Iba, T., Eguchi, Y., Ohtomo, Y., Okamoto, K., Koseki, K., Mayumi, T., Murata, A., Ikeda, T., Ishikura, H., Ueyama, M., Kushimoto, S., Saitoh, D., Endo, S., & Shimazaki, S. (2007). SIRS-associated coagulopathy and organ dysfunction in critically ill patients with thrombocytopenia. Shock, 28(4), 411-417. https://doi.org/10.1097/shk.0b013e31804f7844