siRNA- mediated silencing of the gene for heat shock transcription factor 1 causes hypersensitivity to methylmercury in HEK293 cells

Gi Wook Hwang, Katsunori Ryoke, Jin Yong Lee, Tsutomu Takahashi, Akira Naganuma

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Methylmercury is a hazardous heavy metal compound that can damage the central nervous system. The mechanisms of methylmercury toxicity and the biological defense mechanisms against it remain unclear. We employed gene knockdown using siRNA to search for transcription factors involved in the manifestation of methylmercury toxicity. We found that the inhibition of expression of the gene for heat shock transcription factor 1 (HSF1) sensitized HEK293 cells to methylmercury.

Original languageEnglish
Pages (from-to)851-853
Number of pages3
JournalJournal of Toxicological Sciences
Volume36
Issue number6
DOIs
Publication statusPublished - 2011

Keywords

  • HSF1
  • Methylmercury
  • Transcription factor

ASJC Scopus subject areas

  • Toxicology

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