siRNA-mediated knockdown of the melanocortin 2 receptor accessory protein 2 (MRAP2) gene confers resistance to methylmercury on HEK293 cells

Gi Wook Hwang, Seong Eun Oh, Tsutomu Takahashi, Jin Yong Lee, Akira Naganuma

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Methylmercury is a well-known environmental pollutant that causes serious disorders of the central nervous system as well as a range of other symptoms. We employed small interfering RNA (siRNA) to search for factors in ligand-dependent signal transduction pathways that may be involved in the development of methylmercury toxicity. Melanocortin 2 receptor accessory protein 2 (MRAP2) is involved in the melanocortin pathway. Using siRNA, we found that decreased expression of MRAP2 conferred strong methylmercury resistance in HEK293 cells.

Original languageEnglish
Pages (from-to)947-950
Number of pages4
JournalJournal of Toxicological Sciences
Volume35
Issue number6
DOIs
Publication statusPublished - 2010 Dec

Keywords

  • MRAP2
  • Melanocortin
  • Methylmercury
  • Resistance

ASJC Scopus subject areas

  • Toxicology

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