Abstract
Methylmercury is a well-known environmental pollutant that causes serious disorders of the central nervous system as well as a range of other symptoms. We employed small interfering RNA (siRNA) to search for factors in ligand-dependent signal transduction pathways that may be involved in the development of methylmercury toxicity. Melanocortin 2 receptor accessory protein 2 (MRAP2) is involved in the melanocortin pathway. Using siRNA, we found that decreased expression of MRAP2 conferred strong methylmercury resistance in HEK293 cells.
Original language | English |
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Pages (from-to) | 947-950 |
Number of pages | 4 |
Journal | Journal of Toxicological Sciences |
Volume | 35 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2010 Dec |
Keywords
- MRAP2
- Melanocortin
- Methylmercury
- Resistance
ASJC Scopus subject areas
- Toxicology