siRNA-mediated inhibition of phosphatidylinositol glycan class B (PIGB) confers resistance to methylmercury in HEK293 cells

Gi Wook Hwang, Tatsuya Hayashi, Kayoko Kita, Tsutomu Takahashi, Shusuke Kuge, Akira Naganuma

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

We performed functional gene screening, using a siRNA library targeting 8,500 human genes, to identify proteins that are involved in the susceptibility of cells to methylmercury. Screening revealed that downregulation of the gene for phosphatidylinositol glycan class B (PIGB) by siRNA confers resistance to methylmercury in HEK293 cells.

Original languageEnglish
Pages (from-to)581-583
Number of pages3
JournalJournal of Toxicological Sciences
Volume32
Issue number5
DOIs
Publication statusPublished - 2007 Dec

Keywords

  • HEK293 cells
  • Methylmercury
  • PIGB
  • Resistance
  • siRNA

ASJC Scopus subject areas

  • Toxicology

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