Abstract
We performed functional gene screening, using a siRNA library targeting 8,500 human genes, to identify proteins that are involved in the susceptibility of cells to methylmercury. Screening revealed that downregulation of the gene for phosphatidylinositol glycan class B (PIGB) by siRNA confers resistance to methylmercury in HEK293 cells.
Original language | English |
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Pages (from-to) | 581-583 |
Number of pages | 3 |
Journal | Journal of Toxicological Sciences |
Volume | 32 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2007 Dec |
Keywords
- HEK293 cells
- Methylmercury
- PIGB
- Resistance
- siRNA
ASJC Scopus subject areas
- Toxicology