siRNA-mediated inhibition of phosphatidylinositol glycan class B (PIGB) confers resistance to methylmercury in HEK293 cells

Gi Wook Hwang; Tatsuya Hayashi; Kayoko Kita; Tsutomu Takahashi; Shusuke Kuge; Akira Naganuma

doi:10.2131/jts.32.581

siRNA-mediated inhibition of phosphatidylinositol glycan class B (PIGB) confers resistance to methylmercury in HEK293 cells

Gi Wook Hwang, Tatsuya Hayashi, Kayoko Kita, Tsutomu Takahashi, Shusuke Kuge, Akira Naganuma

PHA - Life and Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

We performed functional gene screening, using a siRNA library targeting 8,500 human genes, to identify proteins that are involved in the susceptibility of cells to methylmercury. Screening revealed that downregulation of the gene for phosphatidylinositol glycan class B (PIGB) by siRNA confers resistance to methylmercury in HEK293 cells.

Original language	English
Pages (from-to)	581-583
Number of pages	3
Journal	Journal of Toxicological Sciences
Volume	32
Issue number	5
DOIs	https://doi.org/10.2131/jts.32.581
Publication status	Published - 2007 Dec

Keywords

HEK293 cells
Methylmercury
PIGB
Resistance
siRNA

ASJC Scopus subject areas

Toxicology

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10.2131/jts.32.581

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siRNA-mediated inhibition of phosphatidylinositol glycan class B (PIGB) confers resistance to methylmercury in HEK293 cells. / Hwang, Gi Wook; Hayashi, Tatsuya; Kita, Kayoko; Takahashi, Tsutomu; Kuge, Shusuke; Naganuma, Akira.

In: Journal of Toxicological Sciences, Vol. 32, No. 5, 12.2007, p. 581-583.

Research output: Contribution to journal › Article › peer-review

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AU - Kuge, Shusuke

AU - Naganuma, Akira

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siRNA-mediated inhibition of phosphatidylinositol glycan class B (PIGB) confers resistance to methylmercury in HEK293 cells

Abstract

Keywords

ASJC Scopus subject areas

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