Single-stranded β-1,3–1,6-glucan as a carrier for improved dissolution and membrane permeation of poorly water-soluble compounds

Hiromasa Uchiyama, Mayu Dowaki, Kazunori Kadota, Hiroshi Arima, Kazumasa Sugiyama, Yuichi Tozuka

Research output: Contribution to journalArticlepeer-review

Abstract

The ability of a water-soluble, single-stranded β-1,3/1,6-glucan (ssβ-glucan), recovered by hydrothermal treatment, to enhance the solubility and membrane permeability of poorly water-soluble compounds was examined. As a poorly water-soluble model compound, quercetin (QUE) was used. The aqueous solubility of spray-dried particles (SDPs) of QUE/ssβ-glucan was significantly enhanced compared with that of the untreated QUE powder and the physical mixture of QUE/ssβ-glucan. Fourier-transform infrared spectra and small-angle X-ray scattering suggested strong interactions between ssβ-glucan and QUE in the SDPs, which was attributable to QUE entrapment in the helical ssβ-glucan structure. The amount of QUE infused into Caco-2 cells from QUE/ssβ-glucan SDPs was 16-fold and 5-fold higher than the amount infused from untreated QUE powder and the physical mixture of QUE/ssβ-glucan, respectively. These results showed that water-soluble ssβ-glucan improved QUE dissolution and membrane permeability.

Original languageEnglish
Article number116698
JournalCarbohydrate Polymers
Volume247
DOIs
Publication statusPublished - 2020 Nov 1

Keywords

  • Permeability enhancement
  • Quercetin
  • Solubility enhancement
  • β-1,3/1,6-Glucan

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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