Single nucleotide polymorphism-based genome-wide linkage analysis in Japanese atopic dermatitis families

Hisako Enomoto, Emiko Noguchi, Shigeruko Iijima, Takenori Takahashi, Kazuhito Hayakawa, Mikako Ito, Toshiyuki Kano, Takeshi Aoki, Yoichi Suzuki, Minori Koga, Mayumi Tamari, Tetsuo Shiohara, Fujio Otsuka, Tadao Arinami

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18 Citations (Scopus)

Abstract

Background: Atopic dermatitis develops as a result of complex interactions between several genetic and environmental factors. To date, 4 genome-wide linkage studies of atopic dermatitis have been performed in Caucasian populations, however, similar studies have not been done in Asian populations. The aim of this study was to identify chromosome regions linked to atopic dermatitis in a Japanese population. Methods: We used a high-density, single nucleotide polymorphism genotyping assay, the Illumina BeadArray Linkage Mapping Panel (version 4) comprising 5,861 single nucleotide polymorphisms, to perform a genome-wide linkage analysis of 77 Japanese families with 111 affected sib-pairs with atopic dermatitis. Results: We found suggestive evidence for linkage with 15q21 (LOD = 2.01, NPL = 2.87, P = .0012) and weak linkage to 1q24 (LOD = 1.26, NPL = 2.44, P = .008). Conclusion: We report the first genome-wide linkage study of atopic dermatitis in an Asian population, and novel loci on chromosomes 15q21 and 1q24 linked to atopic dermatitis. Identification of novel causative genes for atopic dermatitis will advance our understanding of the pathogenesis of atopic dermatitis.

Original languageEnglish
Article number5
JournalBMC Dermatology
Volume7
DOIs
Publication statusPublished - 2007 Sep 28

ASJC Scopus subject areas

  • Dermatology

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    Enomoto, H., Noguchi, E., Iijima, S., Takahashi, T., Hayakawa, K., Ito, M., Kano, T., Aoki, T., Suzuki, Y., Koga, M., Tamari, M., Shiohara, T., Otsuka, F., & Arinami, T. (2007). Single nucleotide polymorphism-based genome-wide linkage analysis in Japanese atopic dermatitis families. BMC Dermatology, 7, [5]. https://doi.org/10.1186/1471-5945-7-5