TY - JOUR
T1 - Single nucleotide polymorphism-based genome-wide linkage analysis in Japanese atopic dermatitis families
AU - Enomoto, Hisako
AU - Noguchi, Emiko
AU - Iijima, Shigeruko
AU - Takahashi, Takenori
AU - Hayakawa, Kazuhito
AU - Ito, Mikako
AU - Kano, Toshiyuki
AU - Aoki, Takeshi
AU - Suzuki, Yoichi
AU - Koga, Minori
AU - Tamari, Mayumi
AU - Shiohara, Tetsuo
AU - Otsuka, Fujio
AU - Arinami, Tadao
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2007/9/28
Y1 - 2007/9/28
N2 - Background: Atopic dermatitis develops as a result of complex interactions between several genetic and environmental factors. To date, 4 genome-wide linkage studies of atopic dermatitis have been performed in Caucasian populations, however, similar studies have not been done in Asian populations. The aim of this study was to identify chromosome regions linked to atopic dermatitis in a Japanese population. Methods: We used a high-density, single nucleotide polymorphism genotyping assay, the Illumina BeadArray Linkage Mapping Panel (version 4) comprising 5,861 single nucleotide polymorphisms, to perform a genome-wide linkage analysis of 77 Japanese families with 111 affected sib-pairs with atopic dermatitis. Results: We found suggestive evidence for linkage with 15q21 (LOD = 2.01, NPL = 2.87, P = .0012) and weak linkage to 1q24 (LOD = 1.26, NPL = 2.44, P = .008). Conclusion: We report the first genome-wide linkage study of atopic dermatitis in an Asian population, and novel loci on chromosomes 15q21 and 1q24 linked to atopic dermatitis. Identification of novel causative genes for atopic dermatitis will advance our understanding of the pathogenesis of atopic dermatitis.
AB - Background: Atopic dermatitis develops as a result of complex interactions between several genetic and environmental factors. To date, 4 genome-wide linkage studies of atopic dermatitis have been performed in Caucasian populations, however, similar studies have not been done in Asian populations. The aim of this study was to identify chromosome regions linked to atopic dermatitis in a Japanese population. Methods: We used a high-density, single nucleotide polymorphism genotyping assay, the Illumina BeadArray Linkage Mapping Panel (version 4) comprising 5,861 single nucleotide polymorphisms, to perform a genome-wide linkage analysis of 77 Japanese families with 111 affected sib-pairs with atopic dermatitis. Results: We found suggestive evidence for linkage with 15q21 (LOD = 2.01, NPL = 2.87, P = .0012) and weak linkage to 1q24 (LOD = 1.26, NPL = 2.44, P = .008). Conclusion: We report the first genome-wide linkage study of atopic dermatitis in an Asian population, and novel loci on chromosomes 15q21 and 1q24 linked to atopic dermatitis. Identification of novel causative genes for atopic dermatitis will advance our understanding of the pathogenesis of atopic dermatitis.
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U2 - 10.1186/1471-5945-7-5
DO - 10.1186/1471-5945-7-5
M3 - Article
C2 - 17900373
AN - SCOPUS:36448935263
VL - 7
JO - BMC Dermatology
JF - BMC Dermatology
SN - 1471-5945
M1 - 5
ER -