Abstract
Recent progress in single-molecule detection techniques is remarkable. These techniques have allowed the accurate determination of myosin-head-induced displacements and how mechanical cycles are coupled to ATP hydrolysis, by measuring individual mechanical events and chemical events of actomyosin directly at the single-molecule level. Here we review our recent work in which we have made detailed measurements of myosin step size and mechanochemical coupling, and propose a model of the myosin motor.
Original language | English |
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Pages (from-to) | 441-447 |
Number of pages | 7 |
Journal | Philosophical Transactions of the Royal Society B: Biological Sciences |
Volume | 355 |
Issue number | 1396 |
DOIs | |
Publication status | Published - 2000 Apr 29 |
Keywords
- Brownian motion
- Lever-arm model
- Myosin step size
- Single-molecule imaging
- Single-molecule manipulation
- Torsional strain
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)