Single-motor mechanics and models of the myosin motor

T. Yanagida; S. Esaki; A. Hikikoshi Iwane; Y. Inoue; Akihiko Ishijima; K. Kitamura; H. Tanaka; M. Tokunaga

doi:10.1098/rstb.2000.0585

Single-motor mechanics and models of the myosin motor

T. Yanagida, S. Esaki, A. Hikikoshi Iwane, Y. Inoue, Akihiko Ishijima, K. Kitamura, H. Tanaka, M. Tokunaga

Division of Organic- and Biomaterials Research

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Recent progress in single-molecule detection techniques is remarkable. These techniques have allowed the accurate determination of myosin-head-induced displacements and how mechanical cycles are coupled to ATP hydrolysis, by measuring individual mechanical events and chemical events of actomyosin directly at the single-molecule level. Here we review our recent work in which we have made detailed measurements of myosin step size and mechanochemical coupling, and propose a model of the myosin motor.

Original language	English
Pages (from-to)	441-447
Number of pages	7
Journal	Philosophical Transactions of the Royal Society B: Biological Sciences
Volume	355
Issue number	1396
DOIs	https://doi.org/10.1098/rstb.2000.0585
Publication status	Published - 2000 Apr 29

Keywords

Brownian motion
Lever-arm model
Myosin step size
Single-molecule imaging
Single-molecule manipulation
Torsional strain

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)

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abstract = "Recent progress in single-molecule detection techniques is remarkable. These techniques have allowed the accurate determination of myosin-head-induced displacements and how mechanical cycles are coupled to ATP hydrolysis, by measuring individual mechanical events and chemical events of actomyosin directly at the single-molecule level. Here we review our recent work in which we have made detailed measurements of myosin step size and mechanochemical coupling, and propose a model of the myosin motor.",

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AU - Yanagida, T.

AU - Esaki, S.

AU - Iwane, A. Hikikoshi

AU - Inoue, Y.

AU - Ishijima, Akihiko

AU - Kitamura, K.

AU - Tanaka, H.

AU - Tokunaga, M.

PY - 2000/4/29

Y1 - 2000/4/29

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AB - Recent progress in single-molecule detection techniques is remarkable. These techniques have allowed the accurate determination of myosin-head-induced displacements and how mechanical cycles are coupled to ATP hydrolysis, by measuring individual mechanical events and chemical events of actomyosin directly at the single-molecule level. Here we review our recent work in which we have made detailed measurements of myosin step size and mechanochemical coupling, and propose a model of the myosin motor.

KW - Brownian motion

KW - Lever-arm model

KW - Myosin step size

KW - Single-molecule imaging

KW - Single-molecule manipulation

KW - Torsional strain

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