Single-motor mechanics and models of the myosin motor

T. Yanagida; S. Esaki; A. Hikikoshi Iwane; Y. Inoue; A. Ishijima; K. Kitamura; H. Tanaka; M. Tokunaga

doi:10.1098/rstb.2000.0585

Single-motor mechanics and models of the myosin motor

T. Yanagida, S. Esaki, A. Hikikoshi Iwane, Y. Inoue, A. Ishijima, K. Kitamura, H. Tanaka, M. Tokunaga

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Recent progress in single-molecule detection techniques is remarkable. These techniques have allowed the accurate determination of myosin-head-induced displacements and how mechanical cycles are coupled to ATP hydrolysis, by measuring individual mechanical events and chemical events of actomyosin directly at the single-molecule level. Here we review our recent work in which we have made detailed measurements of myosin step size and mechanochemical coupling, and propose a model of the myosin motor.

Original language	English
Pages (from-to)	441-447
Number of pages	7
Journal	Philosophical Transactions of the Royal Society B: Biological Sciences
Volume	355
Issue number	1396
DOIs	https://doi.org/10.1098/rstb.2000.0585
Publication status	Published - 2000 Apr 29

Keywords

Brownian motion
Lever-arm model
Myosin step size
Single-molecule imaging
Single-molecule manipulation
Torsional strain

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)

Access to Document

10.1098/rstb.2000.0585

Cite this

@article{bc06577e9e4b4b20a8bbd20ace190b9b,

title = "Single-motor mechanics and models of the myosin motor",

abstract = "Recent progress in single-molecule detection techniques is remarkable. These techniques have allowed the accurate determination of myosin-head-induced displacements and how mechanical cycles are coupled to ATP hydrolysis, by measuring individual mechanical events and chemical events of actomyosin directly at the single-molecule level. Here we review our recent work in which we have made detailed measurements of myosin step size and mechanochemical coupling, and propose a model of the myosin motor.",

keywords = "Brownian motion, Lever-arm model, Myosin step size, Single-molecule imaging, Single-molecule manipulation, Torsional strain",

author = "T. Yanagida and S. Esaki and Iwane, {A. Hikikoshi} and Y. Inoue and A. Ishijima and K. Kitamura and H. Tanaka and M. Tokunaga",

year = "2000",

month = apr,

day = "29",

doi = "10.1098/rstb.2000.0585",

language = "English",

volume = "355",

pages = "441--447",

journal = "Philosophical Transactions of the Royal Society B: Biological Sciences",

issn = "0962-8436",

publisher = "Royal Society of London",

number = "1396",

}

TY - JOUR

T1 - Single-motor mechanics and models of the myosin motor

AU - Yanagida, T.

AU - Esaki, S.

AU - Iwane, A. Hikikoshi

AU - Inoue, Y.

AU - Ishijima, A.

AU - Kitamura, K.

AU - Tanaka, H.

AU - Tokunaga, M.

PY - 2000/4/29

Y1 - 2000/4/29

N2 - Recent progress in single-molecule detection techniques is remarkable. These techniques have allowed the accurate determination of myosin-head-induced displacements and how mechanical cycles are coupled to ATP hydrolysis, by measuring individual mechanical events and chemical events of actomyosin directly at the single-molecule level. Here we review our recent work in which we have made detailed measurements of myosin step size and mechanochemical coupling, and propose a model of the myosin motor.

AB - Recent progress in single-molecule detection techniques is remarkable. These techniques have allowed the accurate determination of myosin-head-induced displacements and how mechanical cycles are coupled to ATP hydrolysis, by measuring individual mechanical events and chemical events of actomyosin directly at the single-molecule level. Here we review our recent work in which we have made detailed measurements of myosin step size and mechanochemical coupling, and propose a model of the myosin motor.

KW - Brownian motion

KW - Lever-arm model

KW - Myosin step size

KW - Single-molecule imaging

KW - Single-molecule manipulation

KW - Torsional strain

UR - http://www.scopus.com/inward/record.url?scp=0034728962&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034728962&partnerID=8YFLogxK

U2 - 10.1098/rstb.2000.0585

DO - 10.1098/rstb.2000.0585

M3 - Article

C2 - 10836497

AN - SCOPUS:0034728962

VL - 355

SP - 441

EP - 447

JO - Philosophical Transactions of the Royal Society B: Biological Sciences

JF - Philosophical Transactions of the Royal Society B: Biological Sciences

SN - 0962-8436

IS - 1396

ER -

Single-motor mechanics and models of the myosin motor

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this