Single-motor mechanics and models of the myosin motor

T. Yanagida, S. Esaki, A. Hikikoshi Iwane, Y. Inoue, A. Ishijima, K. Kitamura, H. Tanaka, M. Tokunaga

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


Recent progress in single-molecule detection techniques is remarkable. These techniques have allowed the accurate determination of myosin-head-induced displacements and how mechanical cycles are coupled to ATP hydrolysis, by measuring individual mechanical events and chemical events of actomyosin directly at the single-molecule level. Here we review our recent work in which we have made detailed measurements of myosin step size and mechanochemical coupling, and propose a model of the myosin motor.

Original languageEnglish
Pages (from-to)441-447
Number of pages7
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Issue number1396
Publication statusPublished - 2000 Apr 29


  • Brownian motion
  • Lever-arm model
  • Myosin step size
  • Single-molecule imaging
  • Single-molecule manipulation
  • Torsional strain

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)


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