Simultaneous Multiplex Potentiostatic Electroanalysis with Liquid-Junction-Removed Reference Electrode System using a Closed Bipolar Electrode

Kumi Y. Inoue, Miho Ikegawa, Takahiro Ito-Sasaki, Shinichiro Takano, Hitoshi Shiku, Tomokazu Matsue

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A novel liquid-junction-removed reference electrode system was developed for simultaneous multiplex amperometry using a closed bipolar electrode. The liquid junction between the reference cell and the sample cell was replaced by a bipolar electrode to ensure electron conductivity in lieu of ionic conductivity in conventional systems. Under the condition where the redox reaction of the analyte at the bipolar electrode in the sample cell was a limiting process, voltammetric and amperometric measurements were performed for quantitative detection of the analytes. After characterization of the system, a chip-type device was fabricated with six sample cells and one reference cell. Simultaneous determination of ferrocene methanol was conducted in six solutions in the 0.1–0.5 mM range. This is the first demonstration of the simultaneous multiplex determination of analytes with a liquid-junction-removed system. Although the potential control problem (which is different to the liquid potential problem of conventional liquid junction) still remains because of the increase of the solid–liquid interface, this system is expected to solve some problems associated with the liquid junction of the reference electrode, including sample contamination by chloride ions and the complicated process of fabricating a reference electrode on a chip.

Original languageEnglish
Pages (from-to)2167-2170
Number of pages4
JournalChemElectroChem
Volume5
Issue number16
DOIs
Publication statusPublished - 2018 Aug 9

Keywords

  • closed bipolar electrode systems
  • electroanalysis
  • electrochemical sensors
  • electrode chips
  • liquid junctions

ASJC Scopus subject areas

  • Catalysis
  • Electrochemistry

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